Monitor TSH levels in thyroidectomy patients undergoing levothyroxine replacement. Severe fluid retention may occur in newly diagnosed CML patients. Patients w/ cardiac disease & risk factors, or signs & symptoms of cardiac failure. Perform ECG & serum troponin level determination in HES/CEL/MDS/MPD, or SM associated w/ high level of eosinophils; if either is abnormal, consider prophylactic use of systemic steroids for 1-2 wk concomitantly w/ imatinib at the start of therapy. Correct significant dehydration & treatment of high uric acid level prior to therapy. May affect ability to drive or use machines. Closely monitor peripheral blood counts & liver enzymes in patients w/ hepatic dysfunction. Women of childbearing potential must use highly effective contraception during treatment. Pregnancy & lactation. Closely monitor growth during therapy in childn.
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