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Fluconazole should be administered carefully to patients with hepatic or renal impairment.
May cause growth of insensitive microorganisms/candida (except Candida albicans and Candida krusei). Superinfection caused by insensitive candida strain may occur hence needed alternative antifungal therapy.
Patients have rarely developed exfoliative fatal cutaneous reactions during treatment with fluconazole.
Not recommended for pregnant women or nursing mothers, except in patients with severe or potentially life-threatening fungal infections in whom fluconazole may be used if the anticipated benefit outweighs the possible risk to the fetus.
Not recommended for children <16 years (unless antifungal treatment is imperative and no suitable alternative agents exist).
In rare cases, as with other azoles, anaphylaxis has been reported.
Fluconazole should be discontinued if bullous lesions or erythema multiforme develop.
