Fluxar Drug Interactions

Fluconazole can inhibit the metabolism of some drugs when administered concomitantly by inhibiting cytochrome P450 (CYP3A4). May cause an increase in plasma concentration of phenytoin, sulfonylurea, cyclosporin, nortriptyline, tributin, tacrolimus and zidovudine and decrease the toxic metabolite production of Sulfametoxazole.
Concomitant administration with rifampicin may result in a decrease of plasma concentration of fluconazole.
Concomitant administration with terfenadine can cause ECG abnormality.
Concomitant administration with astemizole, cisapride and terfenadine should be avoided because of risk in cardiac arrhythmia.
Concomitant administration with oral anticoagulants can increase the effects of anticoagulants and decrease theophylline clearance.
Concomitant administration with sulfonylureas (chlorpropamide, glibenclamide, glipizide and tolbutamide) has been shown to prolong serum half-life. Therefore the possibility of a hypoglycemic episode should be borne in mind.
There were no relevant effects on concomitantly administered oral contraceptives.