Enbrel Drug Interactions

In clinical trials, no interactions have been observed when Enbrel was administered with glucocorticoids, salicylates, NSAIDs, analgesics or methotrexate. No data are available on the effects of vaccination in patients receiving Enbrel (see Precautions).
In a clinical study of patients who were receiving established doses of sulfasalazine, to which Enbrel was added, patients in the combination group experienced a statistically significant decrease in mean white blood cell counts in comparison to groups treated with Enbrel or sulfasalazine alone. The clinical significance of this interaction is unknown.
Concurrent Enbrel and Anakinra Treatment: Patients treated with Enbrel and anakinra were observed to have a higher rate of serious infection when compared with patients treated with Enbrel alone (historical data). In addition, in a double-blind placebo-controlled trial in patients receiving background methotrexate, patients treated with Enbrel and anakinra were observed to have a higher rate of serious infections (7%) and neutropenia than patients treated with Enbrel alone (see Precautions and Adverse Reactions). The combination of Enbrel and anakinra has not demonstrated increased clinical benefit and is therefore not recommended.
Incompatibilities: In the absence of incompatibility studies, Enbrel must not be mixed with other medicinal products.