Sign Out
Each pre-filled syringe also contains the following excipients: Sucrose, sodium chloride, L-arginine hydrochloride, sodium phosphate dibasic anhydrous, sodium phosphate monobasic monohydrate and water for injection.
Etanercept is a human tumour necrosis factor receptor (TNFR) p75 Fc fusion protein produced by recombinant DNA technology in a Chinese hamster ovary (CHO) mammalian expression system. Etanercept is a dimer of a chimeric protein genetically engineered by fusing the extracellular ligand-binding domain of human tumour necrosis factor receptor-2 (TNFR2/p75) to the Fc domain of human IgG1. This Fc component contains the hinge, CH2 and CH3 regions but not the CH1 region of IgG1. Etanercept contains 934 amino acids and has an apparent molecular weight of approximately 150 kilodaltons. The potency is determined by measuring the ability of etanercept to neutralize the TNFα-mediated growth inhibition of A375 cells. The specific activity of etanercept is 1.7 x 106 units/mg.
