Enbrel Dosage/Direction for Use

Enbrel treatment should be initiated and supervised by specialist physicians experienced in the diagnosis and treatment of RA, psoriatic arthritis, ankylosing spondylitis or psoriasis.
Each vial of Enbrel 50 mg must be reconstituted with 1 mL of water for injection before use and administered by SC injection. Adults (18-64 years): Rheumatoid Arthritis: Recommended Dose: Enbrel 25 mg administered twice weekly. Alternatively, 50 mg administered once weekly (as two 25-mg injections given at approximately the same time) has been shown to be safe and effective (see Pharmacology under Actions).
Psoriatic Arthritis and Ankylosing Spondylitis: Recommended Dose: Enbrel 25 mg administered twice weekly or 50 mg once weekly.
Plaque Psoriasis: Recommended Dose: Enbrel 25 mg administered twice weekly. Alternatively, 50 mg given twice weekly may be used for up to 12 weeks followed, if necessary, by a dose of 25 mg twice weekly.
Treatment with Enbrel should continue until remission is achieved, for up to 24 weeks. Treatment should be discontinued in patients who show no response after 12 weeks.
If re-treatment with Enbrel is indicated, guidance on treatment duration should be followed. The dose should be 25 mg twice weekly.
Methotrexate, glucocorticoids, salicylates, NSAIDs or analgesics may be continued during treatment with Enbrel in adults.
Children and Adolescents (≥4 to <18 years): 0.4 mg/kg (up to a maximum of 25 mg/dose) after reconstitution of Enbrel 25 mg in 1 mL of water for injection, given twice weekly as SC injection with an interval of 3-4 days between doses.
Enbrel has not been studied in children <4 years.
Elderly (≥65 years): No dose adjustment is required. Dosage and administration are the same as for adults 18-64 years.
Renal and Hepatic Impairment: No dose adjustment is required.
Administration: Administer Enbrel as SC injection in the thigh, abdomen or upper arm. Give each new injection at least 3 cm from a previous site. Do not inject into areas where the skin is tender, bruised, red or hard.
Patients or caregivers who are to administer Enbrel must be instructed in mixing the powder with the liquid and in injection techniques. The 1st injection should be performed under the supervision of a qualified healthcare professional if Enbrel is to be administered by a patient or caregiver.
Before injection, Enbrel single-use pre-filled syringe should be allowed to reach room temperature (approximately 15-30 min). The needle cover should not be removed while allowing the pre-filled syringe to reach room temperature. The solution should be clear and colorless or pale yellow and practically free from visible particles.