Amnesia, increased degree of grand mal epilepsy, organic brain disease, cardiopulmonary insufficiency, liver & renal function decline, COPD. Cimetidine or tetracycline antibiotics should be consumed w/in 1-2 hr interval. Patients w/ low P diet & long-term use; chronic pulmonary insufficiency, liver, chronic renal disease & personality disorders. Do not drive or use machines during treatment. Renal impairment in long term use. Not recommended for childn <6 yr. May increase chlordiazepoxide toxicity in elderly.