PHARMACOLOGY: The 5-HT3 type serotonin receptor is peripherally located at the terminal of the vagus and central nerve in the chemoreceptor trigger zone of the postrema area. During the chemotherapy process that induces vomiting, enterochromaffin mucous cells release serotonin which stimulates the 5-HT3 receptor. This results in stimulation of the vagus nerve afferent and may induce vomiting. Granisetron is a 5-Hydroxytriptamyne (5-HT3) receptor antagonist that is very selective and potent with antiemetic activity.
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