Amertisan Dosage/Direction for Use

Nausea and vomiting induced by chemotherapy: Adult: Intravenous: Prevention: A dose of 1-3 mg (10-40 mcg/kg) of Granisetron should be administered either as a slow intravenous injection (more than 30 seconds) or diluted in 20-50 mL of infusion fluid and administered over 5 minutes prior to the start of chemotherapy.
Treatment: A dose of 1-3 mg (10-40 mcg/kg) of Granisetron should be administered either as slow intravenous injection (more than 30 seconds) or diluted in 20-50 mL of infusion fluid and administered over 5 minutes.
If needed, additional doses can be administered over 10 minutes after the last administration. The maximum dose of granisetron to be administered over 24 hours should not exceed 9 mg.
Intramuscular: Prevention and treatment: A dose of 3 mg of Granisetron should be administered by IM, 15 minutes prior to the start of chemotherapy. Two subsequent 3 mg dose of Granisetron may be administered, if required, within a 24 hours period.
Children: Intravenous: A dose of 10-40 mcg/kg body weight (up to 3 mg) should be administered by intravenous infusion, diluted in 10-30 mL of infusion fluid and administered over 5 minutes prior to the start of chemotherapy. One additional dose should be administered within 24 hours if required. This additional dose should be given at least 10 minutes after initial infusion.
Intramuscular: There is insufficient data available for the IM use of Granisetron in children.
Nausea and vomiting induced by radiotherapy: Adult: Intravenous: Prevention: A dose of 1-3 mg (10-40 mcg/kg) of Granisetron should be administered as a slow intravenous injection (more than 30 seconds) or diluted in 20-50 mL of infusion fluid and administered over 5 minutes prior to the start of radiotherapy.
Children: There is insufficient data of Granisetron use for the prevention and treatment of radiotherapy-induced nausea and vomiting in children.
Post-operative nausea and vomiting: Adult: Intravenous: Prevention: A dose of 1 mg (10 mcg/kg) of Granisetron should be administered as a slow intravenous injection (more than 30 seconds) before anesthetic induction.
Treatment: A dose of 1 mg (10 mcg/kg) of Granisetron should be administered by slow intravenous injection (more than 30 seconds). The maximum dose for patients who will undergo surgery for surgery is 3 mg Granisetron IV in 1 day.
Children: There is insufficient data of Granisetron use for the prevention and treatment of postoperative nausea and vomiting in children.
Maximum dose and duration of treatment: 2 doses (2 mg) in 1 day.
Special Dosage Instruction: Geriatric: no dosage adjustment required; Renal Impairment: no dosage adjustment required; Hepatic Impairment: no dosage adjusment required.