In human, hepatic enzymes induction by phenobarbital can increase the total clearance of intravenous Granisetron plasma by about a quarter. Granisetron is safe to use with Benzodiazepines, neuroleptics and anti-ulcer drugs which are commonly prescribed along with antiemetics. In addition, Granisetron does not show any drug interaction with emetogenic cancer chemotherapy. Granisetron is safely administered with commonly used anesthetics and analgesics.
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