Venclexta Description

VENCLEXTA tablets contain 10, 50, or 100 mg venetoclax as the active ingredient.
Venetoclax is a BCL-2 inhibitor. It is a light yellow to dark yellow solid with the empirical formula C₄₅H₅₀ClN₇O₇S and a molecular weight of 868.44. Venetoclax is described chemically as 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide).
Venetoclax has very low aqueous solubility.
Dosage Forms and Strengths: See Table 1.

Click on icon to see table/diagram/image

Excipients/Inactive Ingredients: Each tablet also contains the following inactive ingredients: copovidone, colloidal silicon dioxide, polysorbate 80, sodium stearyl fumarate, and calcium phosphate dibasic. In addition, the 10 mg and 100 mg coated tablets include the following: iron oxide yellow, polyvinyl alcohol, polyethylene glycol, talc, and titanium dioxide. The 50 mg coated tablets also include the following: iron oxide yellow, iron oxide red, iron oxide black, polyvinyl alcohol, talc, polyethylene glycol and titanium dioxide.