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TYSABRI contains the active substance (natalizumab). This active ingredient is called a monoclonal antibody. These antibodies work by binding to proteins in the body so that the harmful effect of that protein is removed.
Multiple sclerosis (MS) causes inflammation in the brain that damages the nerve cells. TYSABRI stops the cells that cause inflammation from going into the brain. This reduces nerve damage caused by MS.
Symptoms of multiple sclerosis: The symptoms of MS vary from patient to patient, and the patient may experience some or none of them.
Symptoms can include: walking problems, numbness in the face, arms or legs, problems seeing things, tiredness, feeling off-balance or light headed, bladder and bowel problems, difficulty in thinking and concentrating, depression, acute or chronic pain, sexual problems, and stiffness and muscle spasms. When the symptoms flare up, it is called a relapse (also known as an exacerbation or an attack). When a relapse occurs, the patient may notice the symptoms suddenly, within a few hours, or slowly progressing over several days. The symptoms will then usually improve gradually (this is called a remission).
In clinical trials, TYSABRI approximately halved the progression of the disabling effects of MS and also decreased the number of MS attacks by about two-thirds. When the patient receives TYSABRI he/she might not notice any improvement, but TYSABRI may still be working to prevent the MS becoming worse.
