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Do not use TYSABRI: If the patient is allergic to natalizumab or any of the other ingredients of this medicine (listed Description).
If doctor has told the patient that he/she has PML (progressive multifocal leukoencephalopathy). PML is a rare infection of the brain.
If the doctor tells the patient that he/she has a serious problem with the immune system (due to disease for example, HIV or due to a medicine the patient is taking or has previously taken, e.g. mitoxantrone or cyclophosphamide).
If the patient is taking either beta-interferon or glatiramer acetate. These medicines are for MS and cannot be used with TYSABRI (see Interactions).
If the patient has an active cancer (unless it is a type of skin cancer called basal cell carcinoma).
If the patient is under 18 years of age.
