Simulect Dosage/Direction for Use

Use in adults: Recommended dose: The standard total dose is 40 mg, given in two doses of 20 mg each. The first 20 mg dose should be given within 2 hours prior to transplantation surgery. Simulect must not be administered unless it is absolutely certain that the patient will receive the graft and concomitant immunosuppression. The second 20 mg dose should be given 4 days after transplantation. The second dose should be withheld if severe hypersensitivity reactions to Simulect or graft loss occur (see Precautions).
Mode of administration: Reconstituted Simulect can be administered either as an intravenous infusion over 20-30 minutes or as a bolus injection.
For information on reconstituting Simulect, see Instructions for Use and Handling under Cautions for Usage.
Use in children and adolescents (1-17 years): Recommended dose: In paediatric patients weighing less than 35 kg, the recommended total dose is 20 mg, given in two doses of 10 mg each. In paediatric patients weighing 35 kg or more, the recommended dose is the adult dose, i.e. a total dose of 40 mg, given in two doses of 20 mg each. The first dose should be given within 2 hours prior to transplantation surgery. Simulect must not be administered unless it is absolutely certain that the patient will receive the graft and concomitant immunosuppression. The second dose should be given 4 days after transplantation. The second dose should be withheld if severe hypersensitivity reactions to Simulect or graft loss occur (see Precautions).
Use in the elderly (≥65 years): There are limited data available on the use of Simulect in the elderly, but there is no evidence that elderly patients require a different dosage from younger adult patients.
Mode of administration: Reconstituted Simulect can be administered either as an intravenous infusion over 20-30 minutes or as a bolus injection.
For information on reconstituting Simulect, see Instructions for Use and Handling under Cautions for Usage.