Prophylaxis of acute organ rejection in de novo renal transplantation & is to be used concomitantly w/ ciclosporin for microemulsion & corticosteroid-based immunosuppression or in a triple maintenance immunosuppressive regimen.
Adult 40 mg, given in 2 doses of 20 mg each. The 1st dose should be given w/in 2 hr prior to transplantation surgery. The 2nd dose should be given 4 days after transplantation. Adolescent & childn 1-17 yr (<35 kg) 20 mg given in 2 doses of 10 mg each. Administer as IV infusion over 20-30 min or as bolus inj.
Discontinue if severe hypersensitivity occurs. Patients previously treated & are re-exposed to a subsequent course of therapy; increased risk of developing lymphoproliferative disorders (LPDs) & opportunistic infections. Pregnancy & lactation.
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