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Pharmacology: Pharmacodynamics: Loratadine is a cyproheptadine derivative, structurally related to azatadine. It exhibits potent, long-acting H1-antihistamine activity with no central sedative or anticholinergic effects. In man, nasal and other signs and symptoms of allergic rhinitis are relieved rapidly after oral administration.
Pharmacokinetics: Loratadine is well absorbed and is almost totally metabolised. It has a distribution half-life of one hour and an elimination half-life of 15.3 hours.
Approximately 81% of the 14C labelled dose is excreted in the urine (40%) and faeces (41%) over a 10 day period. Approximately 27% of the dose is eliminated in the urine during the first 24 hours. Pharmacokinetics in healthy adult volunteers and healthy geriatric volunteers are comparable. Steady state levels of loratadine are reached after the fifth dose.
