Interactions with Other Medicaments and Other Forms of Interaction: When administered concurrently with alcohol, Lotin has no potentiating effects as measured by psychomotor performance studies. Loratadine is metabolised by hepatic cytochromes P450 3A4 and 2D6. Concomitant therapy with drugs which inhibit or are metabolised by either system may therefore elevate plasma concentrations of either drug and adverse reactions might result. Studies indicate that cimetidine, which inhibits both enzymes, and erythromycin or ketoconazole, which inhibit P450 3A4, each increased loratadine concentrations, although no adverse effects, clinical or electro-cardiographic, were observed. Other drugs known to inhibit either P450 3A4 or P450 2D6 are quinidine, fluconazole or fluoxetine.
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