During controlled studies, the incidence of adverse effects associated with Lotin treatment was comparable to that associated with placebo. Lotin has no clinically significant sedative or anticholinergic properties. Other events, fatigue, nausea and headache, were reported rarely. Tachycardia and syncope have been reported rarely. Spontaneous adverse events reported rarely, include: Alopecia, anaphylaxis, abnormal hepatic function and supraventricular tachyarrhythmias.