Dormicum Overdosage

Tablet: As with other benzodiazepines, overdose should not present a threat to life unless combined with other CNS depressants (including alcohol).
In the management of overdose with any medicinal product, it should be borne in mind that multiple agents may have been taken.
Following overdose with oral benzodiazepines, vomiting should be induced (within 1 hr) if the patient is conscious or gastric lavage undertaken with the airway protected if the patient is unconscious. If there is no advantage in emptying the stomach, activated charcoal should be given to reduce absorption. Special attention should be paid to respiratory and cardiovascular functions in intensive care. Overdose of benzodiazepines is usually manifested by degrees of central nervous system depression ranging from drowsiness to coma. In mild cases, symptoms include drowsiness, mental confusion and lethargy; in more serious cases, symptoms may include ataxia, hypotonia, hypotension, respiratory depression; rarely coma and very rarely death.
The specific benzodiazepine antagonist flumazenil may be useful for reversing the severe effects of overdose caused by benzodiazepines.
Ampoule: The symptoms of overdose are mainly an intesification of the pharmacological effects; central depression (from oversedation to coma), mental confusion, lethargy and muscle relaxation or paradoxical excitation. In most cases, only observation of vital functions is required.
Extreme overdosage may lead to coma, areflexia, cardiorespiratory depression and apnea, requiring appropriate countermeasures (ventilation, cardiovascular support). The effects of overdosage can be controlled with the benzodiazepine antagonist Anexate (flumazenil).