Dogmakern Tương tác

Contraindicated combinations: Levodopa: reciprocal antagonism between levodopa and neuroleptics (see Contraindications).
Consumption of grapefruit juice during treatment with sulpiride.
Combinations not recommended: Alcohol: alcohol can enhance the sedative effects of neuroleptics. The consumption of alcoholic beverages and medicinal products containing alcohol should be avoided.
Combination with medicinal products that may prolong the QT interval or induce torsade de pointes (see Warnings).
Drugs that induce bradycardia such as beta blockers, calcium channel blockers, inducers of bradycardia such as diltiazem and verapamil, clonidine, guanfacine; digitalis.
Medicinal products that induce hypokalaemia: hypokalaemic diuretics, laxatives, amphotericin B (IV), glucocorticoids, tetracosactide. Hypokalaemia should be corrected.
Class IA antiarrhythmic drugs such as quinidine, disopyramide.
Class III antiarrhythmic drugs such as amiodarone, sotalol.
Other medicinal products such as pimozide, sultopride, haloperidol, thioridazine, methadone, imipramine, lithium, bepridil, cisapride, erythromycin (IV), vincamine (IV), halofantrine, pentamidine, sparfloxacin.
Combinations to be taken into account: Sucralfate: Concomitant administration of sulpiride with sucralfate may reduce plasma levels of sulpiride and may lead to a reduction or loss of therapeutic action. Therefore, sulpiride should be administered at least two hours before the sucralfate.
Antacids: The joint administration of sulpiride with antacids containing magnesium or aluminium salts may cause a decrease in the plasma levels of sulpiride, which may lead to a reduction or loss of therapeutic action. Therefore, sulpiride should be administered at least two hours before antacids.
Antihypertensive agents: antihypertensive effect and possibility of increased occurrence of postural hypotension (additive effect).
CNS depressants: including narcotics, analgesics, sedative H1 antihistamines, barbiturates, benzodiazepines and other anxiolytic drugs, clonidine and derivatives.