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In animal reproduction studies, zoledronic acid was administered SC to rats and rabbits. It was found to be teratogenic at doses ≥0.2 mg/kg body weight in rats. In rabbits, there was no teratogenicity or fetotoxicity but maternotoxicity was found. Zometa should not be used during pregnancy.
It is not known whether zoledronic acid is excreted into human milk. Zometa should not be used by breastfeeding women.
