IV infusion Adult ≥18 yr Complicated intra-abdominal infection 1.5 g every 8 hr for 4-14 days in combination w/ metronidazole 500 mg IV every 8 hr.
Complicated UTI including pyelonephritis 1.5 g every 8 hr for 7 days.
Renal impairment 30-50 mL/min 750 mg every 8 hr,
15-29 mL/min 375 mg every 8 hr.
ESRD on hemodialysis 750 mg as single loading dose followed by 150 mg every 8 hr as maintenance dose for the remainder of the treatment period.
Nosocomial pneumonia including ventilator-associated pneumonia 3 g every 8 hr for 8-14 days.
Renal impairment 30-50 mL/min 1.5 g every 8 hr,
15-29 mL/min 750 mg every 8 hr.
ESRD on hemodialysis 2.25 mg as single loading dose followed by 450 mg every 8 hr as maintenance dose for the remainder of the treatment period.
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