Zefxon Dosage/Direction for Use

ZEFXON INJECTION 40 mg administration once daily is recommended where oral medication is inappropriate. This produces a mean decrease over 24 hours of approximately 90%. In patients with Zollinger-Ellison syndrome the recommended initial dosage of ZEFXON INJECTION is 60 mg once daily. Higher daily doses may be required and the dose should be divided and given twice daily. For aspiration prophylaxis, ZEFXON INJECTION 40 mg should be administered 1 hour before operation. For suspected non-variceal bleeding, bolus ZEFXON INJECTION 40 mg twice daily or ZEFXON INJECTION 80 mg stat followed by an infusion of 8 mg hourly for 72 hours should be administered.
For IV Injection: Dissolved ZEFXON INJECTION 1 vial with the solvent provided to get omeprazole concentration 4 mg/ml. After reconstitution the injection should be given slowly over a period of at least 5 minutes. The IV solution should be used within 4 hours after reconstitution. Do not use if any particles are present in the reconstituted solution and do not co-administered in the same injection area. Before and after administered should always rinse with normal saline or D5W.
For IV infusion: Dissolved ZEFXON INJECTION 1 vial with the solvent provided to get omeprazole concentration 4 mg/ml. Then diluted with normal saline for infusion (0.9% w/v sodium chloride) 40 ml or 5% dextrose for infusion (5% w/v of dextrose) 40 ml. After reconstitution, start the infusion immediately. The duration of IV infusion should be 10 - 30 minutes or continuous infusion 8 mg/hour.
Any unused portion should be discarded. Do not store in refrigerator and do not use if any particles are present in the reconstituted solution.
The constituted solution should not be mixed or co-administered in the same infusion set with any other drug.
The solution should be used within 12 hours when ZEFXON INJECTION is dissolved in normal saline and within 6 hours when dissolved in D5W.