Z-Deen Warnings

For allergy relief, not for common cold.
Warnings (based on the Ministry of Public Health's Announcement): 1. This medicine may cause drowsiness in some patients. Patients who drive or operate machinery or perform activities which may be at risk of falling from the height should take their response to the medicinal product into account.
2. Avoid ethanol or composition with alcohol.
3. Use with caution in children younger than 2 years of age, pregnancy in first trimesters, and women feeding breast milk.
4. If arrhythmia occurs, discontinue the drug and contact a clinician.
5. Use with caution in patients with hepatic impairment.
6. Concomitantly administration of Loratadine and macrolide antibiotics such as erythromycin, clarithromycin; or imidazole antifungals such as ketoconazole, itraconazole, fluconazole; or HIV protease inhibitors; or any CYP450 inhibitors such as cimetidine, metronidazole, zafirlukast, SSRIs, etc. increases drug plasma level 2-3 times. Prolonged QT interval have also been reported.
7. Avoid concomitantly administration of Loratadine with medications which prolonged QT interval such as calcium channel blockers (e.g. bepridil, verapamil), tricyclic antidepressant, cisapride, quinidine.