Vibee Drug Interactions

Vitamin B₁ is not known significant interactions.
Vitamin B₆ interacts with: Altretamine: Pyridoxine may diminish the therapeutic effect of altretamine. Specifically, when altretamine is used in combination with cisplatin the response duration may be diminished. Consider therapy modification.
Barbiturates: High pyridoxine dose (200 mg/day) may increase the metabolism of barbiturates. Monitor therapy.
Fosphenytoin: High pyridoxine dose (80 to 200 mg/day) may increase the metabolism of fosphenytoin. Monitor therapy.
Levodopa: Pyridoxine may diminish the therapeutic effect of levodopa. The concomitant use of pyridoxine and levodopa (in the absence of a dopa decarboxylase inhibitors (DDI)) should be avoided. Use of a dopa decarboxylase inhibitors (eg., carbidopa) with levodopa will essentially eliminate the risk of this interaction. Consider therapy modification.
Phenytoin: High pyridoxine dose (80 to 200 mg/day) may increase the metabolism of phenytoin. Monitor therapy.
Vitamin B₁₂ interacts with: Chloramphenicol: Chloramphenicol may diminish the therapeutic effect of vitamin B₁₂. Monitor therapy.
Colchicine: Colchicine may decrease the serum concentration of cyanocobalamin. Monitor therapy.