Control of serum P levels in adult CKD patients on haemodialysis or peritoneal dialysis. Control development of renal bone disease w/ Ca supplement, 1,25 dihydroxy vit D3 or 1 of its analogues, or calcimimetics.
Initially 1,500 mg Fe (3 tab) daily. Up-/down-titrated in increments of 500 mg Fe (1 tab) daily every 2-4 wk until acceptable serum P level is reached w/ regular monitoring afterwards. Max: 3,000 mg Fe (6 tab) daily.
Patients w/ recent history of peritonitis (w/in last 3 mth), significant gastric or hepatic disorders, & major GI surgery; diabetes. Discoloured (black) stool may visually mask GI bleeding. Fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency. Consider measuring blood levels in concomitant treatment w/ medicinal products w/ narrow therapeutic window. Administer at least 1 hr before or 2 hr after treatment in any medicinal products known to interact eg, alendronate & doxycycline, or w/ potential to interact based on in vitro studies eg, levothyroxine. Pregnancy & lactation. Childn & adolescents <18 yr.
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