Adult Herpes zoster 1,000 mg tid for 7 days.
Herpes simplex infections 500 mg bid. For recurrent episodes, treatment should be for 3 or 5 days. For initial episodes, treatment may have to be extended to 10 days.
Herpes labialis (cold sores) 2 g bid for 1 day. Take 2nd dose 12 hr (no sooner than 6 hr) after the 1st dose.
Prevention (suppression) of recurrences of herpes simplex infections Immunocompetent patient 500 mg once daily. Some patients w/ very frequent recurrences may gain additional benefit from the daily dose of 500 mg being taken as a divided dose (250 mg bid).
Immunocompromised patient 500 mg bid.
Reduction of genital herpes transmission Immunocompetent heterosexual 9 or fewer recurrences/yr: 500 mg once daily by the infected partner.
Prophylaxis of CMV Adult & childn ≥12 yr 2 g qid. Initiate as early as possible post-transplant. Adjust dose according to CrCl. Duration: 90 days. May need to be extended in high risk patient.
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