Ursolin Dosage/Direction for Use

Recommended Dose: General dosing considerations: Gallstone dissolution: Obtain ultrasound images of the gallbladder at 6 - month intervals for the first year of ursodiol therapy to monitor gallstone response. If gallstones appear to have dissolved, continue ursodiol therapy and confirm dissolution on a repeat ultrasound examination within 1 to 3 months. Most patients who eventually achieve complete stone dissolution will show partial or complete dissolution at the first on - treatment reevaluation. If partial stone dissolution is not seen by 12 months of ursodiol therapy, the likelihood of success is greatly reduced.
Safety of use beyond 24 months of therapy has not been established.
Adults: Gallstone dissolution: 8 to 10 mg/kg/day given in 2 or 3 divided doses.
Gallstone prevention: 600 mg/day (300 mg twice daily) in patients undergoing rapid weight loss.
Primary biliary cirrhosis: 10-15 mg/kg/day in 2-4 divided doses with food.
Adjust dosage regimen according to patient's response and tolerance.
Special Populations: Renal function impairment: No specific dosage recommendations at this time.
Hepatic function impairment: No specific dosage recommendations at this time.
Geriatric patients: Select dosage with caution.
Mode of Administration: Administer orally.