Unisia Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Thai FDA Category Presentation/Packing

Concise Prescribing Info

Contents

Candesartan cilexetil 8 mg, amlodipine 5 mg (equiv to amlodipine besilate 6.93 mg)

Indications/Uses

HTN.

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Dosage/Direction for Use

Adult 1 tab once daily.

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Overdosage

View Unisia overdosage for action to be taken in the event of an overdose.

Administration

May be taken with or without food.

Contraindications

Hypersensitivity to dihydropyridines. Pregnancy.

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Special Precautions

Bilateral or unilateral renal artery stenosis, renal & hepatic dysfunction, hyperkalemia. History of drug hypersensitivity. Closely observe BP, renal function in patients on hemodialysis, strict dietary salt restriction, under diuretic therapy, w/ hyponatremia, renal dysfunction & heart failure. Do not administer w/in 24 hr before surgery. May impair ability to drive or operate machinery. Lactation. Childn. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Angioedema, shock, syncope, unconsciousness, acute renal failure, hyperkalemia, hepatic dysfunction or jaundice, agranulocytosis, decreased WBC & platelet count, rhabdomyolysis, interstitial pneumonia, hypoglycemia, AV block.

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Drug Interactions

Intensified hypotensive effect w/ ACE inhibitors, β-blockers, nitroglycerin & sildenafil. Elevated serum K level w/ K-sparing diuretics (spironolactone, triamterene), eplerenone & K supplements. Enhanced antihypertensive effect w/ diuretics (furosemide, trichlormethiazide) & grapefruit juice. Lithium toxicity may occur w/ lithium carbonate. Decreased hypotensive effect & aggravated renal function w/ NSAIDs or COX-2 selective inhibitors (indomethacin). Increased blood conc of amlodipine w/ CYP3A4 inhibitors (erythromycin, diltiazem, ritonavir, itraconazole). Decreased blood conc of amlodipine w/ CYP3A4 inducers (rifampicin).

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Storage

View Unisia storage conditions for details to ensure optimal shelf-life.

Description

View Unisia description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Angiotensin II Antagonists

ATC Classification

C09DB07 - candesartan and amlodipine ; Belongs to the class of angiotensin II receptor blockers (ARBs) and calcium channel blockers. Used in the treatment of cardiovascular disease.

Thai FDA Category

Presentation/Packing

Form

Unisia tab

Packing/Price

3 × 10's

Unisia

Manufacturer:

Celltrion Healthcare

Distributor:

Zuellig Pharma