Initially 100 mg followed by 50 mg 12 hrly by IV infusion over approx 30-60 min. Duration of treatment: 5-14 days (complicated skin & skin structure infections & complicated intra-abdominal infections) or 7-14 days (community-acquired pneumonia). Patients w/ severe hepatic impairment (Child-Pugh C) 100 mg followed by 25 mg 12 hrly.
Patients w/ known hypersensitivity to tetracycline class antibiotics. Anaphylaxis/anaphylactoid reactions, pseudomembranous colitis. May cause permanent tooth discoloration in humans during tooth development. Complicated intra-abdominal infections secondary to clinically apparent intestinal perforation, hepatic dysfunction/failure, photosensitivity, pseudotumor cerebri, anti-anabolic action, pancreatitis, hospital-acquired pneumonia, overgrowth of non-susceptible organisms may occur, mortality imbalance. May impair ability to drive or operate machinery. Patient <18 yr. Pregnancy & lactation.
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