TPIAO Adverse Reactions

Adverse reactions related TPIAO administration are rarely and most of them could recover automatically. The symptomatical treatment was applied for individual patient when they had obvious adverse reaction. In 213 patients, there were 11 (5.16%) cases adverse events occurred in 10 (4.69%) patients were related to TPIAO administration (including "possibly related", "much possibly related" and "related"): 6 (2.82%) cases of fever, 2 (0.94%) cases of chill, 1 (0.47%) case of dizziness, 1 (0.47%) case of vomit, 1 (0.47%) case of bone marrow suppression. Most of the symptoms were slight, which disappeared without special treatment. The results of examination in the laboratory showed that TPIAO injection had no influence on subjects' coagulation function, blood/urine/stool routine, liver and kidney function and ECG etc. 74 subjects accepted dynamic detection of antibodies in TPIAO administration period, only 3 subjects' serum appeared low-titer (1:5) non-neutralizing anti-rhTPO antibody on the 14^th and 28^th day after administration.
The adverse reactions associated with TPIAO (213 subjects): See Table.

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