Torixib Adverse Reactions

Common: asthenia/fatigue, flu-like disease, dizziness, headache, oedema/fluid retention, lower extremity edema, hypertension, abdominal pain, flatulence, diarrhea, dyspepsia, heartburn, epigastric discomfort, nausea, ALT increased, AST increased, alveolar osteitis.
Uncommon to Rare: Blood and lymphatic system disorders: thrombocytopenia, leucopenia.
Infections and infestation: gastroenteritis, upper respiratory infection, urinary tract infection.
Immune system disorders: hypersensitivity reactions, including angioedema, anaphylactic/anaphylactoid reactions including shock.
Metabolism and nutrition disorders: appetite increase or decrease, weight gain, hyperkalemia.
Psychiatric disorders: anxiety, depression, mental acuity decreased, hallucinations, confusion, restlessness.
Nervous system disorders: dysgeusia, insomnia, paresthesia/hypaesthesis, somnolence.
Eye disorders: blurred vision, conjunctivitis.
Ear and labyrinth disorders: tinnitus, vertigo.
Cardiac disorders: congestive heart failure, non-specific ECG changes, myocardial infarction, palpitations, angina, arrhythmia, atrial fibrillation, tachycardia.
Vascular disorders: flushing, cerebrovascular accident, hypertensive crisis, transient ischaemic attack, vasculitis.
Respiratory, thoracic and mediastinal disorders: cough, dyspnea, epistaxis, bronchospasm.
Gastrointestinal disorders: abdominal distention, acid reflux, bowel movement pattern change, constipation, dry mouth, gastroduodenal ulcer, irritable bowel syndrome, oesophagitis, oral ulcers, peptic ulcers including perforation and bleeding (mainly in elderly patients), vomiting, gastritis, pancreatitis.
Hepatobiliary disorders: hepatitis, jaundice, hepatic failure.
Skin and subcutaneous tissue disorders: ecchymosis, facial oedema, pruritus, erythema, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, fixed drug eruption.
Musculoskeletal, connective tissue and bone disorders: muscular cramp/spasm, musculoskeletal pain/stiffness.
Renal and urinary disorders: proteinuria, renal insufficiency, including renal failure.
General disorders and administration site conditions: chest pain.
Investigations: blood urea nitrogen increased, creatinine phosphokinase increased, haematocrit decreased, haemoglobin decreased, hyperkalaemia, leukocytes decreased, platelets decreased, serum creatinine increased, uric acid increased, blood sodium decreased.
The following serious undesirable effects have been reported in association with the use of NSAIDs and cannot be ruled out for Etoricoxib: nephrotoxicity including interstitial nephritis and nephrotic syndrome, hepatotoxicity, including hepatic failure.