Pregnancy & lactation. Tapcom: Patients w/ right ventricular failure caused by pulmonary HTN; CHF, diabetic ketoacidosis or metabolic acidosis, poor-controlled diabetes, aphakia or pseudophakia, intraocular inflammation (iritis, uveitis). Pigmentation in iris & eyelid or hypetrichosis around the eyes may occur. Corneal epithelium disorder may occur during treatment. Closed angle glaucoma. Refrain from activities including driving or operating machinery. Remove contact lenses prior to administration & re-insert after at least 15 min. Parturient women. Elderly. Childn. Tapcom-S: CV diseases (eg, CHD, Prinzmetal's angina & cardiac failure) & hypotension. Patients w/ 1st degree heart block, severe peripheral circulatory disturbance/disorders (ie, severe forms of Raynaud's disease or syndrome), mild/moderate COPD, subject to spontaneous hypoglycaemia or w/ labile diabetes, corneal diseases, angle-closure glaucoma, history of atopy or severe anaphylactic reaction. May mask signs of hyperthyroidism. Avoid abrupt w/drawal of β-blocker therapy. Choroidal detachment. Aphakic & pseudophakic patients w/ torn posterior lens cap or anterior chamber lenses, or w/ known risk factors for cystoid macular oedema or iritis/uveitis. Possible eyelash growth, eyelid skin darkening & increase in iris pigmentation may occur & be permanent. Concomitant use w/ another topical β-adrenergic blocking agent & surgical anesth.
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