Sumatriptan is contraindicated in patients with a history of hypersensitivity to sumatriptan or any component of the formulation.
Sumatriptan is contraindicated in patients with uncontrolled hypertension.
Sumatriptan is contraindicated in patients with hemiplegic or basilar migraine.
Sumatriptan is contraindicated in patients with severe hepatic impairment.
Sumatriptan is contraindicated in patients with ischemic heart disease (angina pectoris, history of myocardial infarction, or documented silent ischemia).
Sumatriptan is contraindicated in patients with coronary artery vasospasm (e.g., Prinzmetal variant angina).
Sumatriptan is contraindicated in patients with a history of stroke or transient ischemic attack, peripheral vascular disease, or ischemic bowel disease.
The concomitant use of ergotamine or derivatives of ergotamine (including methysergide) is contraindicated.
Concurrent administration of monoamine oxidase inhibitors (MAOIs) and sumatriptan is contraindicated. Sumatriptan must not be used within 2 weeks of discontinuation of therapy with MAOIs.