Adult 100-400 mg daily as single dose or in 2 divided doses. Max: 400 mg daily. Otitis media 400 mg once daily or 200 mg every 12 hr for 10-14 days. Pharyngitis & tonsillitis 400 mg once daily or 200 mg every 12 hr for at least 10 days. Resp tract infections & UTI 400 mg once daily or 200 mg every 12 hr for 5-10 days. Uncomplicated gonorrhea 400 mg single dose. Uncomplicated cervical, urethral, rectal gonorrhea infection 400 mg single dose + azithromycin 1 g orally as single dose. Childn 6 mth to 12 yr 8 mg/kg daily in 1 or 2 divided doses. Childn 6 mth to 16 yr Typhoid 5-10 mg/kg bid for 14 days. Renal impairment w/ CrCl 21-59 mL/min or patient on hemodialysis 300 mg daily, ≤20 mL/min or patient on continuous ambulatory peritoneal dialysis 200 mg daily.
Hypersensitivity to penicillins. Stop treatment if fever, skin rash, blisters, detachment of skin & epithelial lining in oral cavity, throat, nose, genital organ & conjunctivitis occur. Patients w/ history of penicillin allergy; personal or familial history of bronchial asthma, rash, urticaria; poor oral nutrition & receiving parenteral nutrition; debilitated status. Vit K deficiency symptoms may develop. Superinfection w/ gm +ve bacteria in prolonged use. False +ve results in urinary glucose determinations; for ketones in urine nitroprusside tests. Renal impairment. Pregnancy & lactation. Elderly.
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