May increase levels/effects of clarithromycin, ifosfamide. Increased level/effects w/ atazanavir, boceprevir, clarithromycin, cobicistat, cyclosporine, strong & moderate CYP2C9 inhibitors; darunavir; eltrombopag, fosamprenavir, gemfibrozil, glyburide, indinavir; lopinavir, nelfinavir; phosphodiesterase-5 inhibitors; rifampin; ritonavir; saquinavir; telaprevir; teriflunomide; tipranavir. Levels/effects may be decreased by glyburide, rifampin. May decrease levels/effects of antihepaciviral combination drugs, asunaprevir, atazanavir, axitinib, bedaquiline, boceprevir, bosutinib, clarithromycin, clozapine, cobimetinib, contraceptives, cyclosporine, CYP3A4 substrates, daclatasvir, darunavir, dasabuvir, daflazacort, elbasvir, estriol, (topical & systemic), fentanyl, flibanserin, fosamprenavir, glyburide, grazoprevir, guanfacine, hydrocodone, ibrutinib, ifosfamide, indinavir, lopinavir, lurasidone, mirodenafil, nelfinavir, nimodipine, nisoldipine, olaparib, palbociclib, phosphodiesterase-5 inhibitors, ranozaline, rolapitant, saquinavir, saxagliptin, simeprevir, simvastatin, sonidegib, telaprevir, tipranavir, ulipristal, velpatasvir, venetoclax, vit K antagonist, zolpidem.