CapAdult 1-4 g daily in divided doses. 250 mg every 6 hr or 500 mg every 12 hr. Severe infections Max: 4 g daily. Childn 25-50 mg/kg daily tid-qid. Renal impairment w/ CrCl >40 mL/min 250 mg every 6 hr or 500 mg every 12 hr, 11-40 mL/min 500 mg every 8-12 hr, 5-10 mL/min 250 mg every 12 hr, <5 mL/min 250 mg every 12-24 hr. SuspChildn Initially 25-100 mg/kg daily. Max: 4 g daily. Childn weighing 30 kg 7.5-30 mL qid, 20 kg 5-20 mL qid, 10 kg 2.5-10 mL qid.
Hypersensitivity to penicillins. Stop using the drug if any signs & symptoms eg, fever, skin rash, blisters, detachment of skin & epithelial lining in oral cavity, throat, nose, genital organ & conjunctivitis occur. Pseudomembranous colitis; resistant bacterial & fungal growth from prolonged use. Administer fluid, electrolytes & protein supplement in severe cases & treat w/ suitable antibiotics in case of severe colitis. Monitor renal & hepatic function in prolonged use. Concomitant use w/ nephrotoxic drugs eg, aminoglycosides, or strong diuretics eg, furosemide. Renal impairment. Pregnancy & lactation.
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