Concise Prescribing Info
Contents
Herpes zoster vaccine [varicella zoster virus glycoprotein E antigen (non-live, recombinant, AS01B adjuvanted)]
Indications/Uses
Prevention of herpes zoster (HZ) & HZ-related complications eg, post-herpetic neuralgia in adults ≥50 yr & ≥18 yr at increased risk of HZ.
Dosage/Direction for Use
IM Inj in deltoid muscle. Primary vaccination schedule of 2 doses (0.5 mL each). Initial dose followed by 2nd dose 2-6 mth later. Immunodeficient or immunosuppressed individual 2nd dose can be given 1-2 mth after initial dose.
Contraindications
Special Precautions
Not indicated for prevention of primary varicella infection. Not to be administered as intravascular, intradermal or SC. Postpone vaccination in subjects suffering from acute severe febrile illness. Syncope (fainting). Patients w/ thrombocytopenia or any coagulation disorder. Consider review of medical history & clinical exam prior to immunisation. Pregnancy & lactation. Increased risk of Guillain-Barré syndrome in elderly ≥65 yr.
Adverse Reactions
Headache; GI symptoms including nausea, vomiting, diarrhoea &/or abdominal pain; myalgia; inj site reactions (eg, pain, redness, swelling), fatigue, chills, fever. Inj site pruritus, malaise.
Drug Interactions
More frequent adverse reactions eg, fever & shivering in concomitant use w/ unadjuvanted seasonal flu vaccine, 23-valent pneumococcal polysaccharide vaccine (PPV23). Administer at different inj site if to be given at the same time as another injectable vaccine.
MIMS Class
Vaccines, Antisera & Immunologicals
ATC Classification
J07BK - Varicella zoster vaccines ; Used for active immunizations.
Presentation/Packing
Form
Shingrix vaccine powd & susp for inj 50 mcg
Packing/Price
1's
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