IV infusion 1st infusion: 50 mg/hr. May be escalated in 50 mg/hr increments every 30 min after 1st 30 min. Max: 400 mg/hr. Subsequent infusion: Initially 100 mg/hr & increased by 100 mg/hr increments at 30 min intervals. Max: 400 mg/hr. Premed: Anti-pyretic & antihistaminic eg, paracetamol & diphenhydramine, or glucocorticoids if not given in combination w/ glucocorticoid-containing chemotherapy.
Follicular non-Hodgkin's lymphoma Combination therapy: 375 mg/m
2 per cycle in combination w/ chemotherapy for up to 8 cycles. Administer on day 1 of each chemotherapy cycle.
Maintenance:
Previously untreated patient after response to induction treatment 375 mg/m
2 once every 2 mth (starting 2 mth after last dose of induction therapy) until disease progression or for max period of 2 yr (total: 12 infusions).
Relapsed/refractory patient after response to induction treatment 375 mg/m
2 once every 3 mth (starting 3 mth after last dose of induction therapy) until disease progression or for max of 2 yr (total: 8 infusions).
Stage III-IV follicular lymphoma & chemoresistant or who are in their 2nd or subsequent relapse after chemotherapy, & retreatment for patients who have responded to previous treatment for relapsed/refractory follicular lymphoma Monotherapy: 375 mg/m
2 once wkly for 4 wk.
Adult diffuse large B cell non-Hodgkin's lymphoma Combination w/ CHOP: 375 mg/m
2 on day 1 of each chemotherapy cycle for 8 cycles after IV infusion of glucocorticoid component of CHOP.
CLL Prophylaxis w/ adequate hydration & administer uricostatics 48 hr prior to start of therapy.
Patients whose lymphocyte counts are >25 x 109/L Administer prednisone/prednisolone 100 mg IV shortly before infusion w/ Ruxience.
Previously untreated & relapsed/refractory patient Combination w/ chemotherapy: 375 mg/m
2 on day 0 of 1st treatment cycle followed by 500 mg/m
2 on day 1 of each subsequent cycle (total: 6 cycles). Give chemotherapy after Ruxience infusion.
RA Premed: Methylprednisolone 100 mg IV 30 min prior to each Ruxience infusion. 1,000 mg followed by 2nd 1,000 mg after 2 wk. Alternative rapid infusion: Initially 250 mg/hr for 1st 30 min, then 600 mg/hr for next 90 min.
GPA & MPA Premed: Methylprednisolone 100 mg IV 30 min prior to each Ruxience infusion. Induction of remission: 375 mg/m
2 once wkly for 4 wk (total: 4 infusions). Administer prior to infusion methylprednisolone 1,000 mg IV daily for 1-3 days followed by oral prednisone 1 mg/kg daily (max: 80 mg daily) during & after 4 wk induction course of treatment. Maintenance: Initiate no sooner than 16 wk after last infusion. Two 500 mg separated by 2 wk, followed by 500 mg every 6 mth.
PV 1,000 mg followed 2 wk later by 2nd 1,000 mg in combination w/ tapering course of glucocorticoids. Maintenance: At 12 & 18 mth, then every 6 mth if needed. In case of relapse, administer 1,000 mg. Administer subsequent infusions no sooner than 16 wk following previous infusion.
Paed Non-Hodgkin's lymphoma 375 mg/m
2 in combination w/ systemic Lymphome Malin B chemotherapy for ped patients ≥6 mth to <18 yr w/ previously untreated, advanced stage CD20 +ve DLBCL/BL/BAL/BLL. 1st infusion: Initially 0.5 mg/kg/hr (max: 50 mg/hr). May be escalated by 0.5 mg/kg/hr every 30 min if no hypersensitivity or infusion-related reactions. Max: 400 mg/hr. Subsequent infusions: Initially 1 mg/kg/hr (max: 50 mg/hr). May be increased by 1 mg/kg/hr every 30 min. Max: 400 mg/hr.
Severe, active GPA & MPA Induction of remission: 375 mg/m
2 once wkly for 4 wk. Prior to 1st Ruxience infusion, administer methylprednisolone IV for 3 daily doses of 30 mg/kg daily (max: 1 g daily) for severe vasculitis symptoms. May give up to 3 additional daily doses of methylprednisolone 30 mg/kg IV. Followed by oral prednisone 1 mg/kg daily (max: 60 mg daily).
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