Increase levels/effects of alcohol, analgesics (eg, opioid); antidiabetics (eg, thiazolidinedione); azelastine (nasal), blonanserin, buprenorphine, CNS depressants, flunitrazepam, hydrocodone, methotrimeprazine, metyrosine, mirtazapine, orphenadrine, oxycodone, paraldehyde, piribedil, pramipexole, ropinirole, rotigotine, SSRI, suvorexant, thalidomide, zolpidem. Levels/effects may be increased by ACE inhibitors, brimonidine (topical), cannabis, chlormethiazole, chlorphenesin, carbamate, dimethindene (topical), doxylamine, dronabinol, droperidol, hydroxyzine, kava kava, lofexidine, Mg sulfate, methotrimeprazine, minocycline, nabilone, oxomemazine, perampanel, rufinamide, Na oxybate, tapentadol, tetrahydrocannabinol, trimeprazine. Decreased levels/effects by mefloquine, mianserin, orlistat.
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