Doses may be given in 2 or 3 divided doses daily. When discontinuing, taper off gradually over at least 1 wk.
Generalized anxiety disorder Initially 150 mg daily. May be increased in steps of 150 mg at wkly intervals to max of 600 mg daily.
Neuropathic pain Initially 150 mg daily. May be increased to 300 mg daily after 3-7 days, then further increase to 600 mg daily after another 7 days.
Diabetic neuropathy Max: 300 mg daily.
Fibromyalgia Initially 150 mg daily. May be increased to 300 mg daily after 1 wk, then further increase to 450 mg daily if necessary.
Epilepsy Initially 150 mg daily. May be increased to 300 mg daily after 1 wk, then further increase to 600 mg daily after another wk.
Renal impairment w/ CrCl ≥60 mL/min 150 mg bid or tid, 300 mg bid or tid, 450 mg bid or tid, 600 mg bid or tid,
30-60 mL/min 75 mg bid or tid, 150 mg bid or tid, 225 mg bid or tid, 300 mg bid or tid,
15-30 mL/min 25-50 mg once daily or bid, 75 mg once daily or bid, 100-150 mg once daily or bid, 150 mg once daily or bid,
<15 mL/min 25 mg once daily, 25-50 mg once daily, 50-75 mg once daily, 75 mg once daily.
Post-hemodialysis supplementary dose 25 mg daily schedule: 25 mg or 50 mg as single dose; 25-50 mg daily schedule: 50 mg or 75 mg as single dose; 50-75 mg daily schedule: 75 mg or 100 mg as single dose; 75 mg daily schedule: 100 mg or 150 mg as single dose.
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