Adults treated w/ Pradaxa (dabigatran etexilate) where rapid reversal of its anticoagulant effects is required for emergency surgery/urgent procedures & in life-threatening or uncontrolled bleeding.
5 g (2 x 2.5 g/50 mL) via IV as 2 consecutive infusions over 5-10 min each or as bolus inj. Flush IV line w/ NaCl 9 mg/mL (0.9%) soln prior to & at the end of infusion. Recurrent bleeding w/ prolonged clotting times/if potential re-bleeding would be life-threatening & prolonged clotting times are observed/2nd emergency surgery or urgent procedure w/ prolonged clotting times Consider 2nd 5 g dose. Restarting antithrombotic therapy: Pradaxa can be re-initiated after 24 hr & other antithrombotic therapy (eg, LMWH) can be started at any time if patient is clinically stable & adequate haemostasis has been achieved.
View Praxbind overdosage for action to be taken in the event of an overdose.
Special Precautions
Hypersensitivity. Hereditary fructose intolerance. Consider resumption of anticoagulant therapy in patients treated w/ dabigatran that may have underlying disease state that may predispose to thromboembolic events. May cause transient proteinuria. Patients on a controlled Na diet. Lactation.
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