CV status should be considered prior to administration. Patients w/ marked HTN, cardiac disorders, advanced arteriosclerotic changes, type 1 IDDM or hyperthyroidism. Increased risk of adverse systemic effects of drug; vasopressor response w/ higher recommended dosage or w/ application to instrument (eg, tonometry), traumatized, diseased, or post-surgical eye or adnexa, or w/ reduced lacrimation during anesth. Monitor rebound miosis effect in older patients undergoing retinal detachment or cataract surgery. Avoid in patients w/ soft contact lenses. Pregnancy & lactation.
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