Sign Out
Pharmacology: No established correlates of protection to pertussis antigens are currently available. Although efficacy or effectiveness data of Pertagen are not available for adolescents and adults including pregnant women, non-inferiority of the immune response of Pertagen was demonstrated as per WHO recommendations (TRS 979, 2013) in adolescents for anti-PT and anti-FHA antibody titers measured by ELISA and for seroconversion rates in a comparative randomized controlled trial with a licensed Tdap vaccine evaluated in effectiveness study. Seroconversion is defined as ≥ 4 folds increase of antibody titers at 28 days after vaccination as compared to baseline titers.
The seroconversion rates of anti-PT and anti-FHA antibody titers were statistically significant higher in subjects vaccinated with Pertagen (respectively 96% and 93%) than in subjects vaccinated with the Tdap comparator vaccine, respectively 55% and 54%. In addition, 1 month after booster vaccination, the neutralizing antibodies against PT antigen were also significantly higher with Pertagen than with the Tdap comparator vaccine.
