3 mL to be vaporised in an inhaler. Max: 6 mL in a single administration. Inhale intermittently to achieve adequate analgesia. Total dose in a wk: 15 mL.
View Penthrox overdosage for action to be taken in the event of an overdose.
Contraindications
Hypersensitivity to Penthrox or any fluorinated anaesth. Known genetic susceptibility to malignant hyperthermia or family history of severe drug reactions to inhaled anaesth. History of signs of liver damage after previous methoxyflurane use or halothane anaesth. Clinically evident CV instability, resp depression. Altered level of consciousness. Clinically significant renal impairment. Use as an anaesth agent.
Nephrotoxicity. Do not administer in patients showing signs of liver damage, especially after previous methoxyflurane or halothane anaesth; w/ underlying hepatic conditions or w/ risks for hepatic dysfunction. Potential effects on BP & heart rate, & CNS. Occupational exposure. Not to be used for relief of breakthrough pain/exacerbations in chronic pain conditions & trauma related pain in closely related episodes for the same patient. Caution as Penthrox contains butylated hydroxytoluene. May have a minor influence on the ability to drive or operate machinery. Pregnancy especially during 1st trimester. Lactation. Elderly w/ hypotension & bradycardia.
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