Post-herpetic neuralgia 150-300 mg daily in 2 or 3 divided doses. Initially 75 mg bid or 50 mg tid & may be increased to 300 mg daily w/in 1 wk, or further increased to 600 mg in 2 or 3 divided doses in patients who do not experience adequate relief following 2-4 wk.
Diabetic neuropathy Initially 150 mg daily in 3 divided doses, may be increased up to 300 mg daily in 3 divided doses w/in 1 wk.
Generalized anxiety disorder 150-600 mg daily in 2 or 3 divided doses. Initially 150 mg daily in 2 or 3 divided doses, may be increased to 300 mg daily after 1 wk, then further increased to 450 mg daily following an additional wk. Max: 600 mg daily after an additional wk.
Epilepsy 150-600 mg daily in 2 or 3 divided doses. Initially 75 mg bid or 50 mg tid, may be increased to max of 600 mg daily.
Fibromyalgia 300-450 mg daily. Initially 75 mg bid, may be increased to 300 mg daily w/in 1 wk, then further increased to 225 mg bid in patients who do not experience adequate benefit.
Renal impairment CrCl ≥60 mL/min Initially 150 mg daily, may be increased to 300 mg daily, then further increased to 450 mg daily up to max of 600 mg daily. All doses should be given in 2-3 divided doses;
30-60 mL/min Initially 75 mg daily, may be increased to 150 mg daily, then further increased to 225 mg daily up to max of 300 mg daily. All doses should be given in 2-3 divided doses;
15-30 mL/min Initially 25-50 mg daily, may be increased to 75 mg daily, then further increased to 100-150 mg daily up to max of 150 mg daily. All doses should be given in 1-2 divided doses;
<15 mL/min Initially 25 mg daily, may be increased to 25-50 mg daily, then further increased to 50-75 mg daily up to max of 75 mg daily. All doses should be given once daily.
Post-hemodialysis supplementary Patient on 25 mg once daily 25 or 50 mg,
25-50 mg once daily 50 or 75 mg,
50-75 mg once daily 75 or 100 mg,
75 mg once daily 100 or 150 mg. All doses should be given as single dose.
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