Metastatic carcinoma of the ovary after failure of 1st-line or subsequent chemotherapy. Breast cancer after failure of combination chemotherapy for metastatic disease or relapse w/in 6 mth of adjuvant chemotherapy. 1st-line treatment of NSCLC in patients who are not candidates for potentially curative surgery or radiation therapy in combination w/ cisplatin. 2nd-line treatment of AIDS-related Kaposi's sarcoma (KS).
Monitor blood counts, cardiac monitoring in patients who develop significant conduction abnormalities, occurence of myelotoxicity during treatment. Severe neutropenia (<500 cells/mm3). Discontinue treatment if severe CV events occur. Hepatic impairment. May affect ability to drive or operate machinery. Childn.
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