History of oesophageal disorders w/ delay oesophageal transit or emptying eg, stricture or achalasia. Patient who are unable to stay in the upright position for at least 30 min after taking Palibone. Active or recent oesophageal or upper GI problems. Consider dental exam w/ appropriate preventive dentistry prior to treatment w/ bisphosphonate in patients w/ concomitant risk factors (eg, cancer, chemotherapy, RT, corticosteroids, poor oral hygiene). Avoid invasive dental procedure during treatment. Treat hypocalcemia & other disturbances of bone & mineral metabolism prior to therapy. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Discontinue if atypical femur fracture is suspected. Examine the contralateral femur in patients who have sustained femoral shaft fracture. Pregnancy & lactation. Childn <18 yr.
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