May increase levels/effects of 5-aminosalicylic acid derivatives, ajmaline, aliskiren, aminoglycosides, aminolevulinic acid (systemic & topical), amodiaquine, anticoagulants, aripiprazole, bisphosphonate derivatives, cyclosporine (systemic), CYP2C8 substrates (high risk w/ inhibitors), deferasirox, desmopressin, dexibuprofen, digoxin, drospirenone, eplerenone, estrogen derivatives, haloperidol, lithium, mecamylamine, MTX, NSAIDs (COX-2 selective), omacetaxine, perhexiline, porfimer, K-sparing diuretics, pralatrexate, prilocaine, quinolones, selexipag, Na nitrate, tacrolimus (systemic), tenofovir products, tolperisone, triflusal, vancomycin, verteporfin, vit K antagonists. Levels/effects may be increased by acemetacin, alcohol (ethyl), ARBs, ACE inhibitors, aspirin; ceritinib, corticosteroids (systemic), cyclosporine (systemic), CYP2C9 inhibitors (moderate), CYP2C9 inhibitors (strong), dapsone (topical), dexketoprofen, felbinac, floctafenine, herbs (anticoagulant/antiplatelet properties), ketorolac (nasal), ketorolac (systemic), loop diuretics, lumacaftor, mifepristone, morniflumate, naftazone, nitric oxide, NSAIDs, pelubiprofen, phenylbutazone, probenecid, SSRIs, Na phosphates, talniflumate, tenoxicam, tetracaine (topical), thiazide & thiazide-like diuretics, tolperisone, TCAs (tertiary amine), triflusal, zaltoprofen. May decrease levels/effects of aliskiren, ARBs, ACE inhibitors, β-blockers, eplerenone, hydralazine, loop/K-sparing/thiazide & thiazide-like diuretics, macimorelin, mifamurtide, prostaglandins (ophth), SSRIs. Levels/effects may be decreased by bile acid sequestrants, CYP2C9 inducers (moderate), dabrafenib, enzalutamide, lumacaftor, rifapentine. Delayed peak conc & increased AUC w/ high fat meal. Avoid concomitant use w/ acemetacin, aminolevulinic acid (systemic), amodiaquine, dexibuprofen, dexketoprofen, floctafenine, ketorolac (nasal, systemic), macimorelin, mecamylamine, mifamurtide, morniflumate, NSAIDs, NSAIDs (COX-2 selective), omacetaxine, pelubiprofen, phenylbutazone, talniflumate, tenoxicam, zaltoprofen.