IV Prevention of chemotherapy & RT-induced nausea & vomitingAdult & ped patient ≥6 mth 0.15 mg/kg as a 15-min infusion beginning 30 min prior to chemotherapy, repeated twice at 4-hr interval following initial dose. Alternatively, 32 mg as a 15-min infusion beginning 30 min prior to chemotherapy. Prevention of post-op nausea & vomitingAdult 4 mg given as a single dose in not <30 sec, preferably over 2-5 min prior to induction of anesth or post-op. Childn 1 mth to 12 yr >40 kg 4 mg given as a single dose over 2-5 min; ≤40 kg 0.1 mg/kg given as a single dose over 2-5 min. Severe hepatic impairment Max daily dose: 8 mg.
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